Tirzepatide is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes.  Controlling high blood sugar helps prevent kidney damage, blindness,  nerve problems, loss of limbs, and sexual function problems.

Mechanism of action:

It works to stimulate first- and second-phase insulin secretion, and reduces glucagon levels, both in a glucose-dependent manner.  Tirzepatide was also shown to delay gastric emptying, lower fasting and  postprandial glucose concentration, decrease food intake, 4 and reduce body weight in patients with type 2 diabetes.

Potential Research Applications:

• Appetite control and satiety studies

• Blood glucose and insulin sensitivity research

• Obesity and metabolic syndrome models

• GLP-1 receptor pathway modulation investigations